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Discussion forum - 49th ERA-EDTA Congress
    Topic - Transplantation - clinical I

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Poster: 722
Visits: 687
Title: Protocol biopsies in pediatric renal transplant recipients on cyclosporine versus tacrolimus
Authors: tim ulinski , Bilal Aoun, Flavio Bandin, Renata Vitkevic,Christine Azema, Stéphane Decramer
Centre: Department of Paediatric Nephrology, Hpital Trousseau

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PROTOCOL BIOPSIES IN PEDIATRIC RENAL TRANSPLANT RECIPIENTS ON CYCLOSPORINE VERSUS TACROLIMUS

Tim Ulinski
Thread initiator
Subspeciality
Reg: 5/6/2012 12:08:00 PM

 Comment# 1

The incidence of acute rejection and graft loss in the first year after renal transplantation (RTx) has decreased since the introduction of potent immunosuppressive protocols. However, chronic allograft nephropathy (CAN) and renal anti-calcineurin toxicity remain important factors leading to graft dysfunction. Several reports have described a correlation between CAN and the number of acute rejection episodes during the first year after RT . Protocol biopsies have been useful for the detection of subclinical rejection and early chronic changes primarily interstitial fibrosis and tubular atrophy. Moreover, protocol biopsies might be of benefit in detecting the signs of anti-calcineurin toxicity which might be important for adapting the immunosuppressive treatment in certain patients. We reported the presence and the frequency of SCR detected by KB in children who were on Tacrolimus (FK) or Cyclosporine (CsA) based protocols.
Comment added on 5/6/2012 12:16:00 PM 
     
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